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Erdafitinib(JNJ-42756493)

Catalog No: 651701
CAS Number: 1346242-81-6
Purity: 98% Min.

Erdafitinib(JNJ-42756493) is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, JNJ-42756493 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.

For research use only. We do not sell to patients.

Chemical Information

NameErdafitinib(JNJ-42756493)
Iupac Chemical NameN1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine 
SynonymsErdafitinib;JNJ-42756493; JNJ 42756493; JNJ42756493; Balversa
Molecular FormulaC25H30N6O2 
Molecular Weight446.54 
SmileCN1N=CC(C2=NC3=CC(N(C4=CC(OC)=CC(OC)=C4)CCNC(C)C)=CC=C3N=C2)=C1
InChiKeyOLAHOMJCDNXHFI-UHFFFAOYSA-N
InChiInChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3
CAS Number1346242-81-6
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Ordering Information

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Formulationyellow solid 
Purity98% Min.
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

651701 - Erdafitinib(JNJ-42756493) | CAS 1346242-81-6

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