Ziftomenib is an oral, potent, and selective small molecule inhibitor that targets the interaction between menin and the KMT2A gene.
For research use only. We do not sell to patients.
| Name | Ziftomenib ( KO-539 ) |
|---|---|
| Iupac Chemical Name | 1-[(2S)-2-[4-(Methanesulfonyl)piperazin-1-yl]propyl]-4-methyl-5-[(4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl)methyl]-1H-indole-2-carbonitrile |
| Synonyms | ziftomenib ; KO-539 ; KO 539 ; KO539 |
| Molecular Formula | C33H42F3N9O2S2 |
| Molecular Weight | 717.88 |
| Smile | N#CC(N1C[C@@H](N2CCN(S(=O)(C)=O)CC2)C)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC(NC)=N5)CC4)=C3C |
| InChiKey | BGGALFIXXQOTPY-NRFANRHFSA-N |
| InChi | InChI=1S/C33H42F3N9O2S2/c1-21(43-11-13-44(14-12-43)49(4,46)47)19-45-25(18-37)15-27-22(2)23(5-6-29(27)45)20-42-9-7-24(8-10-42)39-30-28-16-26(17-33(34,35)36)48-31(28)41-32(38-3)40-30/h5-6,15-16,21,24H,7-14,17,19-20H2,1-4H3,(H2,38,39,40,41)/t21-/m0/s1 |
| CAS Number | 2134675-36-6 |
| Related CAS | 2134675-36-6 |
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |