Muvalaplin是一种小分子,通过干扰载脂蛋白(a)与载脂蛋白B100的结合来抑制脂蛋白(a)的形成。
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| Name | Muvalaplin |
|---|---|
| Iupac Chemical Name | (2S,2'S,2''S)-3,3',3''-((nitrilotris(methylene))tris(benzene-3,1-diyl))tris(2-((R)-pyrrolidin-3-yl)propanoic acid) |
| Synonyms | Muvalaplin ; LY3473329 ; LY-3473329 ; LY 3473329 ; |
| Molecular Formula | C42H54N4O6 |
| Molecular Weight | 710.9 |
| Smile | O=C(O)[C@H]([C@@H]1CNCC1)CC2=CC=CC(CN(CC3=CC(C[C@@H]([C@@H]4CNCC4)C(O)=O)=CC=C3)CC5=CC(C[C@@H]([C@@H]6CNCC6)C(O)=O)=CC=C5)=C2 |
| InChiKey | BRLGERLDHZRETI-BGBFCPIGSA-N |
| InChi | InChI=1S/C42H54N4O6/c47-40(48)37(34-10-13-43-22-34)19-28-4-1-7-31(16-28)25-46(26-32-8-2-5-29(17-32)20-38(41(49)50)35-11-14-44-23-35)27-33-9-3-6-30(18-33)21-39(42(51)52)36-12-15-45-24-36/h1-9,16-18,34-39,43-45H,10-15,19-27H2,(H,47,48)(H,49,50)(H,51,52)/t34-,35-,36-,37-,38-,39-/m0/s1 |
| CAS Number | 2565656-70-2 |
| Related CAS | 2565656-71-3-( Muvalaplin tetrahydrochloride ) |
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | 固体粉末 |
|---|---|
| Purity | ≧98.0% |
| Storage | 短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度 |
| Solubility | 溶于DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| HS Code | 2934200090 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |