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b-AP15

Catalog No.: 73106
Cas No.: 1009817-63-3
Purity : 97% 
73106 - b-AP15 | CAS 1009817-63-3

Catalog number : 73106

CAS number : 1009817-63-3

Molecular Formula : C22H17N3O6 

Molecular Weight : 419.39 

Iupac Chemical Name : (3E,5E)-1-acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one 

Smile : C(C=C)(=O)N1C\C(\C(/C(/C1)=C/C1=CC=C(C=C1)[N+](=O)[O-])=O)=C/C1=CC=C(C=C1)[N+](=O)[O-]

InChiKey : GFARQYQBWJLZMW-JYFOCSDGSA-N

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SynonymsNSC687852; NSC 687852; NSC-687852 
Molecular FormulaC22H17N3O6 
Molecular Weight419.39 
AppearanceYellow solid powder 
Purity97% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC(C=C)(=O)N1C\C(\C(/C(/C1)=C/C1=CC=C(C=C1)[N+](=O)[O-])=O)=C/C1=CC=C(C=C1)[N+](=O)[O-]
InChiKeyGFARQYQBWJLZMW-JYFOCSDGSA-N
InChiInChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
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b-AP15 is a specific inhibitor of the deubiquitinating enzymes Uch37 and Usp14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Treating cells with b-AP15 causes the accumulation of polyubiquitinated proteins, inhibition of proteasomal degradation, upregulation of apoptotic markers and cell death. 

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