b-AP15
Catalog No: 73106
CAS Number: 1009817-63-3
Purity: 97%
b-AP15 is a specific inhibitor of the deubiquitinating enzymes Uch37 and Usp14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Treating cells with b-AP15 causes the accumulation of polyubiquitinated proteins, inhibition of proteasomal degradation, upregulation of apoptotic markers and cell death.
For research use only. We do not sell to patients.
Chemical Information
| Name | b-AP15 |
|---|---|
| Iupac Chemical Name | (3E,5E)-1-acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one |
| Synonyms | NSC687852; NSC 687852; NSC-687852 |
| Molecular Formula | C22H17N3O6 |
| Molecular Weight | 419.39 |
| Smile | C(C=C)(=O)N1C\C(\C(/C(/C1)=C/C1=CC=C(C=C1)[N+](=O)[O-])=O)=C/C1=CC=C(C=C1)[N+](=O)[O-] |
| InChiKey | GFARQYQBWJLZMW-JYFOCSDGSA-N |
| InChi | InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+ |
| CAS Number | 1009817-63-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Yellow solid powder |
|---|---|
| Purity | 97% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
