Zidesamtinib ( NVL-520 )
Catalog No: 20524
CAS Number: 2739829-00-4
Purity: ≧98.0%
Zidesamtinib ( NVL-520 ) is a novel brain-penetrant ROS1-selective tyrosine kinase inhibitor (TKI). NVL-520 exhibits IC50 < 10 nM activity in all ROS1-fusion models.
For research use only. We do not sell to patients.
Chemical Information
| Name | Zidesamtinib ( NVL-520 ) |
|---|---|
| Iupac Chemical Name | (R)-12-ethyl-3-fluoro-5,17-dimethyl-5,12,15,17-tetrahydro-7,11-(metheno)benzo[l]pyrazolo[3,4-g][1,2,3]triazolo[4,5-j][1]oxa[4]azacyclotetradecin-8-amine |
| Synonyms | Zidesamtinib ; NVL-520 ; NVL520 ; NVL 520 |
| Molecular Formula | C22H22FN7O |
| Molecular Weight | 419.46 |
| Smile | NC1=NC=C2C3=C(CC4=NN(C)N=C4C5=CC=C(F)C=C5[C@@H](C)OC1=C2)C=NN3CC |
| InChiKey | DTWUUAFTYSMNQX-GFCCVEGCSA-N |
| InChi | InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9-17(16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25)/t12-/m1/s1 |
| CAS Number | 2739829-00-4 |
| Related CAS | 2739829-00-4 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | ROS1 |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1. NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations. Cancer Discov. 2023 Mar 1;13(3):598-615. doi: 10.1158/2159-8290.CD-22-0968.
Chemical Structure
