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ZSTK474

Catalog No.: 160926006
Cas No.: 475110-96-4
Purity : 98% by HPLC 
160926006 - ZSTK474 | CAS 475110-96-4

Catalog number : 160926006

CAS number : 475110-96-4

Molecular Formula : C19H21F2N7O2 

Molecular Weight : 417.41255 

Iupac Chemical Name : 4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine 

Smile : FC(C1=NC2=C(N1C1=NC(=NC(=N1)N1CCOCC1)N1CCOCC1)C=CC=C2)F

InChiKey : HGVNLRPZOWWDKD-UHFFFAOYSA-N

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SynonymsZSTK474; ZSTK-474; ZSTK 474 
Molecular FormulaC19H21F2N7O2 
Molecular Weight417.41255 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileFC(C1=NC2=C(N1C1=NC(=NC(=N1)N1CCOCC1)N1CCOCC1)C=CC=C2)F
InChiKeyHGVNLRPZOWWDKD-UHFFFAOYSA-N
InChiInChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
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Combination treatment using X-rays then ZSTK474 given orally for 8 days, starting 24h post-irradiation, significantly enhanced cell growth inhibition. The combined effect was also observed for clonogenic survival with continuous ZSTK474 treatment. Western blot analysis showed enhanced phosphorylation of Akt and GSK-3 by X-irradiation, whereas phosphorylation was inhibited by ZSTK474 treatment alone. Treatment with ZSTK474 after X-irradiation also inhibited phosphorylation, and remarkably inhibited xenograft tumor growth. 

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