+86-27-65522453 sales@sun-shinechem.com

YHO-13177

Catalog No.: 6111511
Cas No.: 912287-56-0
Purity : 98% 
6111511 - YHO-13177 | CAS 912287-56-0

Catalog number : 6111511

CAS number : 912287-56-0

Molecular Formula : C20H22N2O3S 

Molecular Weight : 370.47 

Iupac Chemical Name : YHO-13177 

InChiKey :

PackagingPriceAvailabilityPurityEstimated Shipping Time
BulkEnquiryEnquiry
Request Bulk Quote Download MSDSTel:+86-27-65522453 | Email:sales@sun-shinechem.com
Molecular FormulaC20H22N2O3S 
Molecular Weight370.47 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
InChiKey
InChi
Coming soon.

YHO-13177 is a potent and specific inhibitor of BCRP;  potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoproteinCmediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.

YHO-13177 potentiated the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 (HCT116/BCRP) cells and SN-38Cresistant human lung cancer A549 (A549/SN4) cells that express BCRP, but had little effect in the parental cells. In addition, YHO-13177 potentiated the cytotoxicity of SN-38 in human lung cancer NCI-H460 and NCI-H23, myeloma RPMI-8226, and pancreatic cancer AsPC-1 cells that intrinsically expressed BCRP. In contrast, it had no effect on P-glycoproteinCmediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1Cmediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells. YHO-13177 increased the intracellular accumulation of Hoechst 33342, a substrate of BCRP, at 30 minutes and partially suppressed the expression of BCRP protein at more than 24 hours after its treatment in both HCT116/BCRP and A549/SN4 cells .

 

912287-56-0 - Request Bulk Quote

×
912287-56-0 - Request Bulk Quote
Change