XJTU-L453
Catalog No: 24074
CAS Number: 3008290-92-1
Purity: 98% Min.
XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis). XJTU-L453 also has antitumor activity in MCF7 xenograft mice.
For research use only. We do not sell to patients.
Chemical Information
| Name | XJTU-L453 |
|---|---|
| Iupac Chemical Name | (2S)-2-([9-[6-(Ethylamino)pyrimidin-4-yl]-6H-dibenzo[b,d]pyran-3-yl]oxy)propanamide |
| Synonyms | XJTU-L453 |
| Molecular Formula | C22H22N4O3 |
| Molecular Weight | 390.44 |
| Smile | NC([C@@H](OC1=CC(OCC2=C3C=C(C4=NC=NC(NCC)=C4)C=C2)=C3C=C1)C)=O |
| InChiKey | ZAAQWCBZFVQJNN-ZDUSSCGKSA-N |
| InChi | InChI=1S/C22H22N4O3/c1-3-24-21-10-19(25-12-26-21)14-4-5-15-11-28-20-9-16(29-13(2)22(23)27)6-7-17(20)18(15)8-14/h4-10,12-13H,3,11H2,1-2H3,(H2,23,27)(H,24,25,26)/t13-/m0/s1 |
| CAS Number | 3008290-92-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
[1]. Shi X, et al. Rational Design of a Novel 6H-Benzo[c]chromen Series as Selective PI3Kα Inhibitors. J Med Chem. 2024 Aug 19.
Chemical Structure
