WYE-125132
Catalog No: 161009008
CAS Number: 1144068-46-1
Purity: 98% by HPLC
WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells.
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Chemical Information
| Name | WYE-125132 |
|---|---|
| Iupac Chemical Name | 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea |
| Synonyms | WYE 125132; WYE-125132; WYE125132; WYE132; WYE 132�� WYE-132 |
| Molecular Formula | C27H33N7O4 |
| Molecular Weight | 519.6 |
| Smile | C12CN(CC(CC1)O2)C2=C1C(=NC(=N2)C2=CC=C(C=C2)NC(=O)NC)N(N=C1)C1CCC2(OCCO2)CC1 |
| InChiKey | QLHHRYZMBGPBJG-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35) |
| CAS Number | 1144068-46-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
