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WDR5-0103

Catalog No.: 16122845
Cas No.: 890190-22-4
Purity : 98% 
16122845 - WDR5-0103 | CAS 890190-22-4

Catalog number : 16122845

CAS number : 890190-22-4

Molecular Formula : C21H25N3O4 

Molecular Weight : 383.448 

Iupac Chemical Name : WDR5-0103 

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SynonymsWDR 5-0103; WDR-5-0103; WDR50103; WDR-50103; WDR 50103; WD-Repeat Protein 5-0103 
Molecular FormulaC21H25N3O4 
Molecular Weight383.448 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 M). WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription. WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis. 

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