VX-680(Tozasertib,MK-0457)
Catalog No: 52005
CAS Number: 639089-54-6
Purity: 98%
VX-680 (Tozasertib, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. Phase 2.
For research use only. We do not sell to patients.
Chemical Information
| Name | VX-680(Tozasertib,MK-0457) |
|---|---|
| Iupac Chemical Name | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide |
| Synonyms | VX-680;Tozasertib;MK-0457 |
| Molecular Formula | C23H28N8OS |
| Molecular Weight | 464.59 |
| Smile | CC1=CC(=NN1)NC1=NC(=NC(=C1)N1CCN(CC1)C)SC1=CC=C(C=C1)NC(=O)C1CC1 |
| InChiKey | GCIKSSRWRFVXBI-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) |
| CAS Number | 639089-54-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | 5mg/ml in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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