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VX-680(Tozasertib,MK-0457)

Catalog No.: 52005
Cas No.: 639089-54-6
Purity : 98% 
52005 - VX-680(Tozasertib,MK-0457) | CAS 639089-54-6

Catalog number : 52005

CAS number : 639089-54-6

Molecular Formula : C23H28N8OS 

Molecular Weight : 464.59 

Iupac Chemical Name : N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide 

Smile : CC1=CC(=NN1)NC1=NC(=NC(=C1)N1CCN(CC1)C)SC1=CC=C(C=C1)NC(=O)C1CC1

InChiKey : GCIKSSRWRFVXBI-UHFFFAOYSA-N

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SynonymsVX-680;Tozasertib;MK-0457 
Molecular FormulaC23H28N8OS 
Molecular Weight464.59 
Appearanceoff-white solid 
Purity98% 
Solubility5mg/ml in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature 
SmileCC1=CC(=NN1)NC1=NC(=NC(=C1)N1CCN(CC1)C)SC1=CC=C(C=C1)NC(=O)C1CC1
InChiKeyGCIKSSRWRFVXBI-UHFFFAOYSA-N
InChiInChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
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VX-680 (Tozasertib, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. Phase 2. 

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