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VLX1570

Catalog No.: 611932
Cas No.: 1431280-51-1
Purity : 98% 
611932 - VLX1570 | CAS 1431280-51-1

Catalog number : 611932

CAS number : 1431280-51-1

Molecular Formula : C23H17F2N3O6 

Molecular Weight : 469.39 

Iupac Chemical Name : VLX1570 

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SynonymsVLX 1570; VLX-1570 
Molecular FormulaC23H17F2N3O6 
Molecular Weight469.39 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM.

VLX1570 inhibits proteasome deubiqu-itinase activity and induces accumulation of high molecularweight  polyubiquitinated proteins in cells.
Knock-down of USP14 in multiple myeloma cells induces loss of cell viability
VLX1570 induces accumulation of polyubiquitin chains and elicits apoptosis of multiple myeloma cells
VLX1570 induces apoptosis and cell death of MM cells


 

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