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VH298

Catalog No.: 18581
Cas No.: 2097381-85-4
Purity : >98%
18581 - VH298  | CAS 2097381-85-4

Catalog number : 18581

CAS number : 2097381-85-4

Molecular Formula : C27H33N5O4S

Molecular Weight : 523.652

Iupac Chemical Name : (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Smile : O=C([C@H]1N(C([C@@H](NC(C2(CC2)C#N)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3

InChiKey : NDVQUNZCNAMROD-RZUBCFFCSA-N

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SynonymsVH-298; VH 298; VH298.
Molecular FormulaC27H33N5O4S
Molecular Weight523.652
AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
SmileO=C([C@H]1N(C([C@@H](NC(C2(CC2)C#N)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
InChiKeyNDVQUNZCNAMROD-RZUBCFFCSA-N
InChiInChI=1S/C27H33N5O4S/c1-16-21(37-15-30-16)18-7-5-17(6-8-18)12-29-23(34)20-11-19(33)13-32(20)24(35)22(26(2,3)4)31-25(36)27(14-28)9-10-27/h5-8,15,19-20,22,33H,9-13H2,1-4H3,(H,29,34)(H,31,36)/t19-,20+,22-/m1/s1
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VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism.

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