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VE-822 ( Berzosertib )

Catalog No.: 51607
Cas No.: 1232416-25-9
Purity : 98% 

VE-822(Berzosertib), an analogue of VE-821 with increased potency and selectivity against ATR, increased solubility and good pharmacokinetic properties was shown to potently radiosensitise pancreatic cancer cell lines in vitro.VE-822 was the first selective ATR inhibitor to enter clinical development, and is now known as VX-970. In a recent study, published by Vertex Pharmaceuticals, VX-970 (VE-822) was shown to markedly sensitise a panel of non-small cell lung cancer cell lines, but not normal cells, to multiple DNA damaging drugs, namely cisplatin, oxaliplatin, gemcitabine, etoposide and SN38, the active metabolite of irinotecan.

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Chemical Information

NameVE-822 ( Berzosertib )
Iupac Chemical Name 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine
SynonymsVE-822,VX-970;VE822;VE 822;Berzosertib; M6620; M-6620; M 6620;
Molecular FormulaC24H25N5O3S 
Molecular Weight463.55 
CAS Number1232416-25-9
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationyellow solid 
Storage3 years -20ºCpowder 
Solubility5mg/ml in DMSO 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Cell study
Animal study
Clinical study
Not available

Chemical Structure

51607 - VE-822 ( Berzosertib ) | CAS 1232416-25-9

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