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UNC0642

Catalog No: 16071013
CAS Number: 1481677-78-4
Purity: 98% by HPLC 

UNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties. UNC0642 exhibits an in vitro IC50 <15 nM with selectivity > 100-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. In cells, UNC0642 results in a potent reduction of H3K9me2 in MDA MB231 cells with IC50 = 106 nM.  

For research use only. We do not sell to patients.

Chemical Information

NameUNC0642
Iupac Chemical Name2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine 
SynonymsUNC0642; UNC-0642 
Molecular FormulaC29H44F2N6O2 
Molecular Weight546.7078 
SmileFC1(CCN(CC1)C1=NC2=CC(=C(C=C2C(=N1)NC1CCN(CC1)C(C)C)OC)OCCCN1CCCC1)F
InChiKeyRNAMYOYQYRYFQY-UHFFFAOYSA-N
InChiInChI=1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34)
CAS Number1481677-78-4
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Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 &ordm;C for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16071013 - UNC0642 | CAS 1481677-78-4

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