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UNC0638

Catalog No.: 82403
Cas No.: 1255580-76-7
Purity : 98% 
82403 - UNC0638 | CAS 1255580-76-7

Catalog number : 82403

CAS number : 1255580-76-7

Molecular Formula : C30H47N5O2 

Molecular Weight : 509.73 

Iupac Chemical Name : 2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 

Smile : C1(CCCCC1)C1=NC2=CC(=C(C=C2C(=N1)NC1CCN(CC1)C(C)C)OC)OCCCN1CCCC1

InChiKey : QOECJCJVIMVJGX-UHFFFAOYSA-N

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SynonymsUNC 0638; UNC-0638 
Molecular FormulaC30H47N5O2 
Molecular Weight509.73 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC1(CCCCC1)C1=NC2=CC(=C(C=C2C(=N1)NC1CCN(CC1)C(C)C)OC)OCCCN1CCCC1
InChiKeyQOECJCJVIMVJGX-UHFFFAOYSA-N
InChiInChI=1S/C30H47N5O2/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23/h20-24H,4-19H2,1-3H3,(H,31,32,33)
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UNC0638 is an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 treatment of a variety of cell lines resulted in lower global H3K9me2 levels, equivalent to levels observed for small hairpin RNA knockdown of G9a and GLP with the functional potency of UNC0638 being well separated from its toxicity. 

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