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UC-112

Catalog No.: 6111407
Cas No.: 383392-66-3
Purity : 98% 
6111407 - UC-112 | CAS 383392-66-3

Catalog number : 6111407

CAS number : 383392-66-3

Molecular Formula : C22H24N2O2 

Molecular Weight : 348.44 

Iupac Chemical Name : UC-112 

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Molecular FormulaC22H24N2O2 
Molecular Weight348.44 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM).

UC-112 also potently inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 M. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO (MG-132) rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112.

 

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