曲古柳菌素A, 也称为TSA,是一种HDAC抑制剂. 在生长阶段开始时,TSA会抑制真核细胞周期。TSA可以通过干扰组蛋白(组蛋白去乙酰酶,HDAC)去除乙酰基来改变基因表达,从而改变DNA转录因子在染色质内的DNA分子的能力。
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Chemical Information
| Name | 曲古柳菌素A |
| Iupac Chemical Name | (R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
| Synonyms | 曲古柳菌素A |
| Molecular Formula | C17H22N2O3 |
| Molecular Weight | 302.36818 |
| Smile | CN(C1=CC=C(C=C1)C([C@@H](/C=C(/C=C/C(=O)NO)\C)C)=O)C |
| InChiKey | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| InChi | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
| CAS Number | 58880-19-6 |
| Related CAS | |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
| Bulk | | Enquiry | Enquiry | Enquiry |
| Formulation | 类白色至白色固体 |
| Purity | 98% |
| Storage | 短期可在0-4度保存,数天至数月;长期可在-20度保存三年。 |
| Solubility | 可溶于DMSO |
| Handling | |
| Shipping Condition | 可在常温下运输 |
| HS Code | |
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