Tretazicar (CB1954)
Catalog No: 100906
CAS Number: 21919-05-1
Purity: 98%
Tretazicar is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA.
For research use only. We do not sell to patients.
Chemical Information
| Name | Tretazicar (CB1954) |
|---|---|
| Iupac Chemical Name | 5-(aziridin-1-yl)-2,4-dinitrobenzamide |
| Synonyms | CB-1954; CB 1954 |
| Molecular Formula | C9H8N4O5 |
| Molecular Weight | 252.18 |
| Smile | N1(CC1)C=1C(=CC(=C(C(=O)N)C1)[N+](=O)[O-])[N+](=O)[O-] |
| InChiKey | WOCXQMCIOTUMJV-UHFFFAOYSA-N |
| InChi | InChI=1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14) |
| CAS Number | 21919-05-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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