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Tirabrutinib free base ( ONO-4059 )

Catalog No: 17031303
CAS Number: 1351636-18-4
Purity: ≧98.0%

Tirabrutinib, also known as ONO-4059 is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) inhibitor. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

For research use only. We do not sell to patients.

Chemical Information

NameTirabrutinib free base ( ONO-4059 )
Iupac Chemical Name(R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one 
SynonymsONO-4059 ; ONO4059 ; ONO 4059 ; ONO-4059 ; GS 4059 ; GS-4059 ; GS4059 ; ONO-WG-307 ; Tirabrutinib 
Molecular FormulaC25H22N6O3 
Molecular Weight454.49 
SmileNC1=C2N(C(N(C2=NC=N1)[C@H]1CN(CC1)C(C#CC)=O)=O)C1=CC=C(C=C1)OC1=CC=CC=C1
InChiKeySEJLPXCPMNSRAM-GOSISDBHSA-N
InChiInChI=1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28)/t18-/m1/s1
CAS Number1351636-18-4
Related CAS1351636-18-4

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-177 0271 9238   Email : sales@sun-shinechem.com
FormulationOff-white solid
Purity≧98.0%
StorageDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
SolubilitySoluble in DMSO 
HandlingRefer to MSDS
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code2934200090
Coming soon.
TargetsBTK inhibitor
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17031303 - Tirabrutinib free base ( ONO-4059 ) | CAS 1351636-18-4

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