Tipiracil HCl
Catalog No.: 17030710
Cas No.: 183204-72-0
Purity : 98%
Catalog number : 17030710
CAS number : 183204-72-0
Molecular Formula : C9H12Cl2N4O2
Molecular Weight : 279.12318
Iupac Chemical Name : 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride
Smile : Cl.ClC=1C(NC(NC1CN1C(CCC1)=N)=O)=O
InChiKey : KGHYQYACJRXCAT-UHFFFAOYSA-N
| Packaging | Price | Availability | Purity | Estimated Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry |
| Synonyms | TAS-1-462, MA-1; Tipiracil HCl, TPI; TAS-102 |
|---|---|
| Molecular Formula | C9H12Cl2N4O2 |
| Molecular Weight | 279.12318 |
| Appearance | off-white solid |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Storage | 3 years -20ºCpowder |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| Smile | Cl.ClC=1C(NC(NC1CN1C(CCC1)=N)=O)=O |
| InChiKey | KGHYQYACJRXCAT-UHFFFAOYSA-N |
| InChi | InChI=1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H |
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Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials. TAS-102 consists of the cytotoxin Trifluridine and the thymidine phosphorylase inhibitor (TPI) tipiracil. Trifluridine is incorporated into DNA during DNA synthesis and inhibits tumor cell growth. Tipiracil protects trifluridine from being broken down when taken orally. TAS-102 was approved in Japan in 2015.
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