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Tipiracil HCl

Catalog No.: 17030710
Cas No.: 183204-72-0
Purity : 98% 
17030710 - Tipiracil HCl | CAS 183204-72-0

Catalog number : 17030710

CAS number : 183204-72-0

Molecular Formula : C9H12Cl2N4O2 

Molecular Weight : 279.12318 

Iupac Chemical Name : 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride 

Smile : Cl.ClC=1C(NC(NC1CN1C(CCC1)=N)=O)=O

InChiKey : KGHYQYACJRXCAT-UHFFFAOYSA-N

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SynonymsTAS-1-462, MA-1; Tipiracil HCl, TPI; TAS-102 
Molecular FormulaC9H12Cl2N4O2 
Molecular Weight279.12318 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCl.ClC=1C(NC(NC1CN1C(CCC1)=N)=O)=O
InChiKeyKGHYQYACJRXCAT-UHFFFAOYSA-N
InChiInChI=1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
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Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials. TAS-102 consists of the cytotoxin Trifluridine and the thymidine phosphorylase inhibitor (TPI) tipiracil. Trifluridine is incorporated into DNA during DNA synthesis and inhibits tumor cell growth. Tipiracil protects trifluridine from being broken down when taken orally. TAS-102 was approved in Japan in 2015. 

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