Tinengotinib ( TT-00420)
Catalog No: 20553
CAS Number: 2230490-29-4
Purity: ≧98.0%
Tinengotinib ( TT-00420) is a novel multiple kinase inhibitor that strongly inhibited Aurora A/B, FGFR1/2/3, VEGFRs, JAK1/2, and CSF1R in biochemical assays. Exposure to tinengotinib specifically inhibited proliferation across all subtypes of TNBC (Triple-negative breast cancer) in vitro and in vivo, while leaving luminal breast cancer cells intact.
For research use only. We do not sell to patients.
Chemical Information
| Name | Tinengotinib ( TT-00420) |
|---|---|
| Iupac Chemical Name | 4-(5-(2-chlorophenyl)-3-methyl-1,10-dihydropyrazolo[4,3-b]pyrido[4,3-e][1,4]diazepin-8-yl)morpholine |
| Synonyms | Tinengotinib; Tinengotinibum; TT-00420 ; TT 00420 ; TT00420 |
| Molecular Formula | C20H19ClN6O |
| Molecular Weight | 394.86 |
| Smile | CC1=NNC2=C1N=C(C3=CC=CC=C3Cl)C(C=NC(N4CCOCC4)=C5)=C5N2 |
| InChiKey | DQFCVOOFMXEPOC-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H19ClN6O/c1-12-18-20(26-25-12)23-16-10-17(27-6-8-28-9-7-27)22-11-14(16)19(24-18)13-4-2-3-5-15(13)21/h2-5,10-11H,6-9H2,1H3,(H2,23,25,26) |
| CAS Number | 2230490-29-4 |
| Related CAS | 2230490-29-4 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Yellow solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | multiple kinase inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
