Tebapivat
Catalog No: 25137
CAS Number: 2283422-04-6
Purity: 98% Min.
Tebapivat is a pyruvate kinase activator.
For research use only. We do not sell to patients.
Chemical Information
| Name | Tebapivat |
|---|---|
| Iupac Chemical Name | 6-[(6-aminopyridin-2-yl)methyl]-4-methyl-2-[(1H-pyrazol-3-yl)methyl]-4,6-dihydro-5H-[1,3]thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5-one |
| Synonyms | AG-946; AG 946; AG946; PKR activator 2; Tebapivat |
| Molecular Formula | C18H16N8OS |
| Molecular Weight | 392.44 |
| Smile | O=C1C(N(C)C2=C3SC(CC4=NNC=C4)=N2)=C3C=NN1CC5=NC(N)=CC=C5 |
| InChiKey | DIUOELXIXSCFCR-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H16N8OS/c1-25-15-12(16-17(25)23-14(28-16)7-10-5-6-20-24-10)8-21-26(18(15)27)9-11-3-2-4-13(19)22-11/h2-6,8H,7,9H2,1H3,(H2,19,22)(H,20,24) |
| CAS Number | 2283422-04-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Liu T, Padyana AK, Judd ET, Jin L, Hammoudeh D, Kung C, Dang L. Structure-
Based Design of AG-946, a Pyruvate Kinase Activator. ChemMedChem. 2024 Mar
1;19(5):e202300559. doi: 10.1002/cmdc.202300559. Epub 2024 Feb 2. PMID:
38109501.
2: Xu JZ, Vercellotti GM. Pyruvate kinase activators: targeting red cell
metabolism in sickle cell disease. Hematology Am Soc Hematol Educ Program. 2023
Dec 8;2023(1):107-113. doi: 10.1182/hematology.2023000467. PMID: 38066891;
PMCID: PMC10727103.
Chemical Structure
