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TX1-85-1

Catalog No.: 17030713
Cas No.: 1603845-32-4
Purity : 98% 
17030713 - TX1-85-1 | CAS 1603845-32-4

Catalog number : 17030713

CAS number : 1603845-32-4

Molecular Formula : C32H36N8O3 

Molecular Weight : 580.693 

Iupac Chemical Name : N-(5-(1-(4-(4-Acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-phenoxyphenyl)acrylamide 

Smile : C(C)(=O)N1CCN(CC1)C1CCC(CC1)N1N=C(C=2C1=NC=NC2N)C=2C=CC(=C(C2)NC(C=C)=O)OC2=CC=CC=C2

InChiKey : FYICDSWKKFSYOM-UHFFFAOYSA-N

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SynonymsTX1-85-1; TX1 85-1; TX185-1; TX1851; TX 1851; TX-1851 
Molecular FormulaC32H36N8O3 
Molecular Weight580.693 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileC(C)(=O)N1CCN(CC1)C1CCC(CC1)N1N=C(C=2C1=NC=NC2N)C=2C=CC(=C(C2)NC(C=C)=O)OC2=CC=CC=C2
InChiKeyFYICDSWKKFSYOM-UHFFFAOYSA-N
InChiInChI=1S/C32H36N8O3/c1-3-28(42)36-26-19-22(9-14-27(26)43-25-7-5-4-6-8-25)30-29-31(33)34-20-35-32(29)40(37-30)24-12-10-23(11-13-24)39-17-15-38(16-18-39)21(2)41/h3-9,14,19-20,23-24H,1,10-13,15-18H2,2H3,(H,36,42)(H2,33,34,35)
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TX1-85-1 is ErbB3 inhibitor. TX2-121-1 may exert Her3-dependent pharmacology through an allosteric mechanismthereby disrupting interactions between Her3 and other proteins such as Her3 or cMet consistent with results presented here and distinct from conventional kinase inhibitors, which block catalytic function. Her3 (also known as ErbB3) belongs to the epidermal growth factor receptor tyrosine kinases and is well credentialed as an anti-cancer target but is thought to be 'undruggable' using ATP-competitive small molecules because it lacks appreciable kinase activity. 

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