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TX1-85-1

Catalog No.: 17030713
Cas No.: 1603845-32-4
Purity : 98% 

TX1-85-1 is ErbB3 inhibitor. TX2-121-1 may exert Her3-dependent pharmacology through an allosteric mechanismthereby disrupting interactions between Her3 and other proteins such as Her3 or cMet consistent with results presented here and distinct from conventional kinase inhibitors, which block catalytic function. Her3 (also known as ErbB3) belongs to the epidermal growth factor receptor tyrosine kinases and is well credentialed as an anti-cancer target but is thought to be 'undruggable' using ATP-competitive small molecules because it lacks appreciable kinase activity. 

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Chemical Information

NameTX1-85-1
Iupac Chemical NameN-(5-(1-(4-(4-Acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-phenoxyphenyl)acrylamide 
SynonymsTX1-85-1; TX1 85-1; TX185-1; TX1851; TX 1851; TX-1851 
Molecular FormulaC32H36N8O3 
Molecular Weight580.693 
SmileC(C)(=O)N1CCN(CC1)C1CCC(CC1)N1N=C(C=2C1=NC=NC2N)C=2C=CC(=C(C2)NC(C=C)=O)OC2=CC=CC=C2
InChiKeyFYICDSWKKFSYOM-UHFFFAOYSA-N
InChiInChI=1S/C32H36N8O3/c1-3-28(42)36-26-19-22(9-14-27(26)43-25-7-5-4-6-8-25)30-29-31(33)34-20-35-32(29)40(37-30)24-12-10-23(11-13-24)39-17-15-38(16-18-39)21(2)41/h3-9,14,19-20,23-24H,1,10-13,15-18H2,2H3,(H,36,42)(H2,33,34,35)
CAS Number1603845-32-4
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Ordering Information

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Formulationoff-white solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17030713 - TX1-85-1 | CAS 1603845-32-4

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