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TWS-119

Catalog No.: 17030204
Cas No.: 601514-19-6
Purity : 98% 
17030204 - TWS-119 | CAS 601514-19-6

Catalog number : 17030204

CAS number : 601514-19-6

Molecular Formula : C18H14N4O2 

Molecular Weight : 318.34 

Iupac Chemical Name : 3-((6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenol 

Smile : NC=1C=C(C=CC1)C1=CC2=C(N=CN=C2OC=2C=C(C=CC2)O)N1

InChiKey : VPVLEBIVXZSOMQ-UHFFFAOYSA-N

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SynonymsTWS-119; TWS119; TWS 119 
Molecular FormulaC18H14N4O2 
Molecular Weight318.34 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileNC=1C=C(C=CC1)C1=CC2=C(N=CN=C2OC=2C=C(C=CC2)O)N1
InChiKeyVPVLEBIVXZSOMQ-UHFFFAOYSA-N
InChiInChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
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TWS-119 is a potent and selective inhibitor of glycogen synthase kinase-3 (IC50 = 30 nM). TWS119 could activate Wnt/-catenin pathway and up-regulate the expression of CD62L in a dose-dependent manner, but it decreased the expression of CD107a. Glycogen synthase kinase (GSK)-3, a constitutively active serine-threonine kinase, acts as a key regulator of major signaling pathways, including the Wnt, Hedgehog, and Notch pathways. 

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