TVB-3664
Catalog No: 2041503
CAS Number:
Purity: 98% Min.
TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression.
For research use only. We do not sell to patients.
Chemical Information
| Name | TVB-3664 |
|---|---|
| Iupac Chemical Name | 4-(1-(5-(4-(methoxymethyl)-2-(trifluoromethyl)-1H-imidazol-5-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile |
| Synonyms | TVB-3664; TVB 3664; TVB3664. |
| Molecular Formula | C25H23F3N4O2 |
| Molecular Weight | 468.48 |
| Smile | CC1=C(C2=C(COC)N=C(C(F)(F)F)N2)C=C(C(N3CC(C4=CC=C(C#N)C=C4)C3)=O)C(C)=C1 |
| InChiKey | YFEOVRCUSPPGFZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C25H23F3N4O2/c1-14-8-15(2)20(9-19(14)22-21(13-34-3)30-24(31-22)25(26,27)28)23(33)32-11-18(12-32)17-6-4-16(10-29)5-7-17/h4-9,18H,11-13H2,1-3H3,(H,30,31) |
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Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Heuer TS, Ventura R, Mordec K, Lai J, Fridlib M, Buckley D, Kemble G. FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression. EBioMedicine. 2017 Feb;16:51-62. doi: 10.1016/j.ebiom.2016.12.012. Epub 2016 Dec 24. PubMed PMID: 28159572.
Chemical Structure
