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TPX-0005

Catalog No.: 18423
Cas No.: 1802220-02-5
Purity : >98%
18423 - TPX-0005  | CAS 1802220-02-5

Catalog number : 18423

CAS number : 1802220-02-5

Molecular Formula : C18H18FN5O2

Molecular Weight : 355.3734

Iupac Chemical Name : (7S,13R)-11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one

Smile : O=C1NC[C@H](C)OC2=CC=C(F)C=C2[C@@H](C)NC3=NC4=C1C=NN4C=C3

InChiKey : FIKPXCOQUIZNHB-WDEREUQCSA-N

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SynonymsTPX-0005; TPX 0005; TPX0005.
Molecular FormulaC18H18FN5O2
Molecular Weight355.3734
AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO, not in water
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
SmileO=C1NC[C@H](C)OC2=CC=C(F)C=C2[C@@H](C)NC3=NC4=C1C=NN4C=C3
InChiKeyFIKPXCOQUIZNHB-WDEREUQCSA-N
InChiInChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
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TPX-0005 is a Src/FAK/Janus kinase 2 (JAK2) inhibitor. TPX-0005 plus EGFR TKI suppressed expression and activation of RTKs and downstream signaling intermediates.

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