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Catalog No: 236271
CAS Number: 2044686-42-0
Purity: ≧97.0%

Alvocidib Prodrug TP-1287 is an orally bioavailable, highly soluble phosphate prodrug of alvocidib, a potent inhibitor of cyclin-dependent kinase-9 (CDK9), with potential antineoplastic activity. Upon administration of the phosphate prodrug TP-1287, the prodrug is enzymatically cleaved at the tumor site and the active moiety alvocidib is released. Alvocidib targets and binds to CDK9, thereby reducing the expression of CDK9 target genes such as the anti-apoptotic protein MCL-1, and inducing G1 cell cycle arrest and apoptosis in CDK9-overexpressing cancer cells.

For research use only. We do not sell to patients.

Chemical Information

Iupac Chemical Name2-(2-chlorophenyl)-5-hydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4-oxo-4H-chromen-7-yl dihydrogen phosphate
SynonymsTP-1287 ; Alvocidib Phosphate ; Alvocidib Prodrug TP-1287 ; TP1287 ; TP 1287 ;
Molecular FormulaC21H21ClNO8P
Molecular Weight481.82
CAS Number2044686-42-0
Related CAS2044686-42-0

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationYellow solid
StorageDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
SolubilitySoluble in DMSO
HandlingRefer to MSDS
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code2934200090
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Cell study
Animal study
Clinical study
Not available

Chemical Structure

236271 - TP1287 | CAS 2044686-42-0

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