TP1287
Catalog No: 236271
CAS Number: 2044686-42-0
Purity: ≧97.0%
Alvocidib Prodrug TP-1287 is an orally bioavailable, highly soluble phosphate prodrug of alvocidib, a potent inhibitor of cyclin-dependent kinase-9 (CDK9), with potential antineoplastic activity. Upon administration of the phosphate prodrug TP-1287, the prodrug is enzymatically cleaved at the tumor site and the active moiety alvocidib is released. Alvocidib targets and binds to CDK9, thereby reducing the expression of CDK9 target genes such as the anti-apoptotic protein MCL-1, and inducing G1 cell cycle arrest and apoptosis in CDK9-overexpressing cancer cells.
For research use only. We do not sell to patients.
Chemical Information
| Name | TP1287 |
|---|---|
| Iupac Chemical Name | 2-(2-chlorophenyl)-5-hydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4-oxo-4H-chromen-7-yl dihydrogen phosphate |
| Synonyms | TP-1287 ; Alvocidib Phosphate ; Alvocidib Prodrug TP-1287 ; TP1287 ; TP 1287 ; |
| Molecular Formula | C21H21ClNO8P |
| Molecular Weight | 481.82 |
| Smile | OC1=C2C(OC(C3=C(Cl)C=CC=C3)=CC2=O)=C([C@@H]4[C@H](O)CN(C)CC4)C(OP(O)(O)=O)=C1 |
| InChiKey | YRNFLVUMZIRYKY-BLLLJJGKSA-N |
| InChi | InChI=1S/C21H21ClNO8P/c1-23-7-6-12(16(26)10-23)19-18(31-32(27,28)29)9-15(25)20-14(24)8-17(30-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,16,25-26H,6-7,10H2,1H3,(H2,27,28,29)/t12-,16+/m0/s1 |
| CAS Number | 2044686-42-0 |
| Related CAS | 2044686-42-0 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Yellow solid |
|---|---|
| Purity | ≧97.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
