TH588
Catalog No: 17011728
CAS Number: 1609960-31-7
Purity: 98%
TH588 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. TH588 a first-in-class nudix hydrolase family inhibitor that potently and selectively engages and inhibits the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitor binds in the active site of MTH1.
For research use only. We do not sell to patients.
Chemical Information
| Name | TH588 |
|---|---|
| Iupac Chemical Name | N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine |
| Synonyms | TH-588; TH 588 |
| Molecular Formula | C13H12Cl2N4 |
| Molecular Weight | 295.17 |
| Smile | C1(CC1)NC1=NC(=NC(=C1)C1=C(C(=CC=C1)Cl)Cl)N |
| InChiKey | PNMYJIOQIAEYQL-UHFFFAOYSA-N |
| InChi | InChI=1S/C13H12Cl2N4/c14-9-3-1-2-8(12(9)15)10-6-11(17-7-4-5-7)19-13(16)18-10/h1-3,6-7H,4-5H2,(H3,16,17,18,19) |
| CAS Number | 1609960-31-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
