TG6-10-1
Catalog No: 17011727
CAS Number: 1415716-58-3
Purity: 98%
TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2. Systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of cyclooxygenase-2 from principal forebrain neurons, namely reduced delayed mortality, accelerated recovery from weight loss, reduced brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely. TG6-10-1 shows low-nanomolar antagonist activity against EP2.
For research use only. We do not sell to patients.
Chemical Information
| Name | TG6-10-1 |
|---|---|
| Iupac Chemical Name | (E)-N-(2-(2-(trifluoromethyl)-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide |
| Synonyms | TG 6-10-1; TG-6-10-1; TP6101; TP-6101; TP 6101 |
| Molecular Formula | C23H23F3N2O4 |
| Molecular Weight | 448.44 |
| Smile | FC(C=1N(C2=CC=CC=C2C1)CCNC(\C=C\C1=CC(=C(C(=C1)OC)OC)OC)=O)(F)F |
| InChiKey | WUYOECAJFJFUFC-CMDGGOBGSA-N |
| InChi | InChI=1S/C23H23F3N2O4/c1-30-18-12-15(13-19(31-2)22(18)32-3)8-9-21(29)27-10-11-28-17-7-5-4-6-16(17)14-20(28)23(24,25)26/h4-9,12-14H,10-11H2,1-3H3,(H,27,29)/b9-8+ |
| CAS Number | 1415716-58-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
