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TG101209

Catalog No.: 17011726
Cas No.: 936091-14-4
Purity : 98% 
17011726 - TG101209 | CAS 936091-14-4

Catalog number : 17011726

CAS number : 936091-14-4

Molecular Formula : C26H35N7O2S 

Molecular Weight : 509.67 

Iupac Chemical Name : N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide 

Smile : C(C)(C)(C)NS(=O)(=O)C1=CC(=CC=C1)NC1=NC(=NC=C1C)NC1=CC=C(C=C1)N1CCN(CC1)C

InChiKey : JVDOKQYTTYUYDV-UHFFFAOYSA-N

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SynonymsTG-101209; TG 101209 
Molecular FormulaC26H35N7O2S 
Molecular Weight509.67 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileC(C)(C)(C)NS(=O)(=O)C1=CC(=CC=C1)NC1=NC(=NC=C1C)NC1=CC=C(C=C1)N1CCN(CC1)C
InChiKeyJVDOKQYTTYUYDV-UHFFFAOYSA-N
InChiInChI=1S/C26H35N7O2S/c1-19-18-27-25(29-20-9-11-22(12-10-20)33-15-13-32(5)14-16-33)30-24(19)28-21-7-6-8-23(17-21)36(34,35)31-26(2,3)4/h6-12,17-18,31H,13-16H2,1-5H3,(H2,27,28,29,30)
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TG101209 is a novel and potent JAK2 inhibitor, which induced dose- and time-dependent cytotoxicity in a variety of multiple myeloma (MM) cell lines. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosis in myeloma cell lines and patient-derived plasma cells. Exploring the mechanism of action of TG101209 indicated downregulation of pJak2, pStat3, and Bcl-xl levels with upregulation of pErk and pAkt levels indicating cross talk between signaling pathways. TG101209 , when used in combination with the PI3K inhibitor LY294002, demonstrated synergistic cytotoxicity against myeloma cells. 

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