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TG101209

Catalog No.: 17011726
Cas No.: 936091-14-4
Purity : 98% 

TG101209 is a novel and potent JAK2 inhibitor, which induced dose- and time-dependent cytotoxicity in a variety of multiple myeloma (MM) cell lines. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosis in myeloma cell lines and patient-derived plasma cells. Exploring the mechanism of action of TG101209 indicated downregulation of pJak2, pStat3, and Bcl-xl levels with upregulation of pErk and pAkt levels indicating cross talk between signaling pathways. TG101209 , when used in combination with the PI3K inhibitor LY294002, demonstrated synergistic cytotoxicity against myeloma cells. 

For research use only. We do not sell to patients.

Chemical Information

NameTG101209
Iupac Chemical NameN-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide 
SynonymsTG-101209; TG 101209 
Molecular FormulaC26H35N7O2S 
Molecular Weight509.67 
SmileC(C)(C)(C)NS(=O)(=O)C1=CC(=CC=C1)NC1=NC(=NC=C1C)NC1=CC=C(C=C1)N1CCN(CC1)C
InChiKeyJVDOKQYTTYUYDV-UHFFFAOYSA-N
InChiInChI=1S/C26H35N7O2S/c1-19-18-27-25(29-20-9-11-22(12-10-20)33-15-13-32(5)14-16-33)30-24(19)28-21-7-6-8-23(17-21)36(34,35)31-26(2,3)4/h6-12,17-18,31H,13-16H2,1-5H3,(H2,27,28,29,30)
CAS Number936091-14-4
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17011726 - TG101209 | CAS 936091-14-4

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