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TDZD-8

Catalog No.: 161009029
Cas No.: 327036-89-5
Purity : 98% by HPLC 
161009029 - TDZD-8 | CAS 327036-89-5

Catalog number : 161009029

CAS number : 327036-89-5

Molecular Formula : C10H10N2O2S 

Molecular Weight : 222.26 

Iupac Chemical Name : 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 

Smile : C(C1=CC=CC=C1)N1C(N(SC1=O)C)=O

InChiKey : JDSJDASOXWCHPN-UHFFFAOYSA-N

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SynonymsTDZD8; TDZD-8; TDZD 8. GSK3 Inhibitor I; NP 01139. 
Molecular FormulaC10H10N2O2S 
Molecular Weight222.26 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC(C1=CC=CC=C1)N1C(N(SC1=O)C)=O
InChiKeyJDSJDASOXWCHPN-UHFFFAOYSA-N
InChiInChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
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TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Treatment of glioblastoma stem cells with TDZD-8 resulted in an inhibition of proliferation and self-renewal of these cells. 

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