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TCS-OX2-29

Catalog No.: 61117
Cas No.: 372523-75-6
Purity : 98% 
61117 - TCS-OX2-29 | CAS 372523-75-6

Catalog number : 61117

CAS number : 372523-75-6

Molecular Formula : C23H31N3O3 

Molecular Weight : 397.51 

Iupac Chemical Name : TCS-OX2-29 

Smile : CC(C)(C)[C@@H](C(=O)N1CCc2cc(c(cc2C1)OC)OC)NCc3ccncc3.Cl

InChiKey : NHKNHFJTMINMBP-ZMBIFBSDSA-N

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SynonymsTCS OX2 29 
Molecular FormulaC23H31N3O3 
Molecular Weight397.51 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC(C)(C)[C@@H](C(=O)N1CCc2cc(c(cc2C1)OC)OC)NCc3ccncc3.Cl
InChiKeyNHKNHFJTMINMBP-ZMBIFBSDSA-N
InChiInChI=1S/C23H31N3O3.ClH/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26;/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3;1H/t21-;/m1./s1
MDLMFCD12828766
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TCS-OX2-29 is a potent and selective OX2 receptor antagonist with IC50 of 40 nM. Displays >250-fold selectivity for OX2 over OX1. 

TCS-OX2-29 shows selectivity for ion channels, and transporters (<30% inhibition at 10 M), which includes G-protein coupled receptors associated with food intake including galanin and neuripeptide Y. 
TCS-OX2-29 Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.

 

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