TC-H 106
Catalog No: 17011720
CAS Number: 937039-45-7
Purity: 98%
TC-H 106, also known as Pimelic Diphenylamide 106, is a class I HDAC inhibitor, demonstrating no activity against class II HDACs. TC-H 106 is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, although inhibition for these enzymes occurs through different mechanisms. TC-H 106 also has preference toward HDAC3 with K(i) of approximately 14 nm, 15 times lower than the K(i) for HDAC1. In comparison, the hydroxamate suberoylanilide hydroxamic acid does not discriminate between these enzymes and exhibits a fast-on/fast-off inhibitory mechanism.
For research use only. We do not sell to patients.
Chemical Information
| Name | TC-H 106 |
|---|---|
| Iupac Chemical Name | N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide |
| Synonyms | TC-H106; TC-H-106; TCH-106; TCH 106; TCH106; Histone Deacetylase Inhibitor VII; Pimelic Diphenylamide 106. |
| Molecular Formula | C20H25N3O2 |
| Molecular Weight | 339.439 |
| Smile | NC1=C(C=CC=C1)NC(CCCCCC(=O)NC1=CC=C(C=C1)C)=O |
| InChiKey | WTKBRPXPNAKVEQ-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25) |
| CAS Number | 937039-45-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
