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TAK1 INHIBITOR

Catalog No.: 1791412
Cas No.: 1326712-16-6
Purity : >98%
1791412 - TAK1 INHIBITOR | CAS 1326712-16-6

Catalog number : 1791412

CAS number : 1326712-16-6

Molecular Formula : C22H19ClN6O2S

Molecular Weight : 466.94

Iupac Chemical Name : trans-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)-3-chlorofuro[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}cyclohexanol

Smile : O[C@H]1CC[C@H](N2N=CC(C3=CN=C(N)C4=C3C(Cl)=C(C5=C(SN=N6)C6=CC=C5)O4)=C2)CC1

InChiKey : IXXBWYJJOYSCNJ-JOCQHMNTSA-N

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SynonymsTAK1 INHIBITOR
Molecular FormulaC22H19ClN6O2S
Molecular Weight466.94
AppearanceOff-white solid
Purity>98%
SolubilitySoluble in DMSO, not in water
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs
SmileO[C@H]1CC[C@H](N2N=CC(C3=CN=C(N)C4=C3C(Cl)=C(C5=C(SN=N6)C6=CC=C5)O4)=C2)CC1
InChiKeyIXXBWYJJOYSCNJ-JOCQHMNTSA-N
InChiInChI=1S/C22H19ClN6O2S/c23-18-17-15(11-8-26-29(10-11)12-4-6-13(30)7-5-12)9-25-22(24)20(17)31-19(18)14-2-1-3-16-21(14)32-28-27-16/h1-3,8-10,12-13,30H,4-7H2,(H2,24,25)/t12-,13-
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IC50 Value: 28 nM [1] TAK1 inhibitor is a potent, relatively selective inhibitor of TAK1 with good pharmacokinetic properties in mice, which was active in an in vivo model of ovarian cancer. in vitro: Compound 13a showed an excellent balance of TAK1 activity and kinase cellular selectivity (>300X for Aurora B and >1000X for KDR).

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