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T-5224

Catalog No.: 16070909
Cas No.: 530141-72-1
Purity : 98% by HPLC 
16070909 - T-5224 | CAS 530141-72-1

Catalog number : 16070909

CAS number : 530141-72-1

Molecular Formula : C29H27NO8 

Molecular Weight : 517.52658 

Iupac Chemical Name : 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxybenzo[d]isoxazol-6-yl)methoxy)phenyl)propanoic acid 

Smile : C1(CCCC1)OC1=CC(=C(C(=O)C=2C=CC(=C(C2)CCC(=O)O)OCC2=CC3=C(C(=NO3)O)C=C2)C=C1)O

InChiKey : DALCQQSLNPLQFZ-UHFFFAOYSA-N

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SynonymsT5224; T-5224 
Molecular FormulaC29H27NO8 
Molecular Weight517.52658 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC1(CCCC1)OC1=CC(=C(C(=O)C=2C=CC(=C(C2)CCC(=O)O)OCC2=CC3=C(C(=NO3)O)C=C2)C=C1)O
InChiKeyDALCQQSLNPLQFZ-UHFFFAOYSA-N
InChiInChI=1S/C29H27NO8/c31-24-15-21(37-20-3-1-2-4-20)8-10-22(24)28(34)19-6-11-25(18(14-19)7-12-27(32)33)36-16-17-5-9-23-26(13-17)38-30-29(23)35/h5-6,8-11,13-15,20,31H,1-4,7,12,16H2,(H,30,35)(H,32,33)
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T-5224 is a selective inhibitor of c-Fos/activator protein-1. T-5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T-5224 has been investigated in phase II human clinical trials. T-5224 may be a promising new treatment for septic kidney injury. Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of cellular processes including proliferation, apoptosis, differentiation, survival, cell migration, and transformation. Accumulating evidence supports that AP-1 plays an important role in several severe disorders including cancer, fibrosis, and organ injury, as well as inflammatory disorders such as asthma, psoriasis, and rheumatoid arthritis. 

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