Spastazoline
Spastazoline is a novel inhibitor for aaa+ (atpases associated with diverse cellular activities) proteins, inhibiting the microtubule-severing aaa+ protein spastin
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Chemical Information
| Name | Spastazoline |
|---|---|
| Iupac Chemical Name | (R)-N-(5-(tert-Butyl)-1H-pyrazol-3-yl)-2-(3-isopropylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Synonyms | Spastazoline |
| Molecular Formula | C20H30N8 |
| Molecular Weight | 382.516 |
| Smile | CC([C@@H]1CN(C2=NC(NC3=NNC(C(C)(C)C)=C3)=C4C(NC=C4)=N2)CCN1)C |
| InChiKey | HNOLTAKAPDKZRY-AWEZNQCLSA-N |
| InChi | InChI=1S/C20H30N8/c1-12(2)14-11-28(9-8-21-14)19-24-17-13(6-7-22-17)18(25-19)23-16-10-15(26-27-16)20(3,4)5/h6-7,10,12,14,21H,8-9,11H2,1-5H3,(H3,22,23,24,25,26,27)/t14-/m0/s1 |
| CAS Number | 2351882-11-4 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Cupido T, Pisa R, Kelley ME, Kapoor TM. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 May;15(5):444-452. doi: 10.1038/s41589-019-0225-6. Epub 2019 Feb 18. PubMed PMID: 30778202; PubMed Central PMCID: PMC6558985.
2: Pisa R, Cupido T, Steinman JB, Jones NH, Kapoor TM. Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins. Cell Chem Biol. 2019 Jun 26. pii: S2451-9456(19)30182-5. doi: 10.1016/j.chembiol.2019.06.001. [Epub ahead of print] PubMed PMID: 31257183.
Chemical Structure
