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Sotrastaurin

Catalog No.: 16071004
Cas No.: 425637-18-9
Purity : 98% by HPLC 
16071004 - Sotrastaurin | CAS 425637-18-9

Catalog number : 16071004

CAS number : 425637-18-9

Molecular Formula : C25H22N6O2 

Molecular Weight : 438.48118 

Iupac Chemical Name : 3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 

Smile : N1C=C(C2=CC=CC=C12)C=1C(NC(C1C1=NC(=NC2=CC=CC=C12)N1CCN(CC1)C)=O)=O

InChiKey : OAVGBZOFDPFGPJ-UHFFFAOYSA-N

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SynonymsAEB071 
Molecular FormulaC25H22N6O2 
Molecular Weight438.48118 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileN1C=C(C2=CC=CC=C12)C=1C(NC(C1C1=NC(=NC2=CC=CC=C12)N1CCN(CC1)C)=O)=O
InChiKeyOAVGBZOFDPFGPJ-UHFFFAOYSA-N
InChiInChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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Sotrastaurin, also known as AEB-071, is an orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible tumor cells. This agent may act synergistically with other chemotherapeutic agents. 

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