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Sobetirome

Catalog No.: 16070907
Cas No.: 211110-63-3
Purity : 98% by HPLC 
16070907 - Sobetirome | CAS 211110-63-3

Catalog number : 16070907

CAS number : 211110-63-3

Molecular Formula : C20H24O4 

Molecular Weight : 328.408 

Iupac Chemical Name : 2-(4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid 

Smile : OC1=C(C=C(CC2=C(C=C(OCC(=O)O)C=C2C)C)C=C1)C(C)C

InChiKey : QNAZTOHXCZPOSA-UHFFFAOYSA-N

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SynonymsGC-1; GC1; GC 1; QRX-431 
Molecular FormulaC20H24O4 
Molecular Weight328.408 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileOC1=C(C=C(CC2=C(C=C(OCC(=O)O)C=C2C)C)C=C1)C(C)C
InChiKeyQNAZTOHXCZPOSA-UHFFFAOYSA-N
InChiInChI=1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23)
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Sobetirome, also known as GC-1 and QRX-431, is a hyroid hormone beta-receptor agonist. Sobetirome inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol through activation of liver TRbeta without stimulating cardiac function through TRalpha activation in the heart. The tissue selective thyromimetic properties of sobetirome have been demonstrated in numerous animal models, which led to its clinical development as a novel cholesterol-lowering agent. 

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