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Senaparib

Catalog No.: 20103002
Cas No.: 1401682-78-7
Purity : ≧98.0%

Senaparib (IMP4297) is a novel agent targeting PARP (poly-ADP ribose polymerase) with strong antitumor activity in preclinical studies. Senaparib demonstrated encouraging clinical benefit and a favorable tolerability profile in patients with advanced solid tumour.

For research use only. We do not sell to patients.

Chemical Information

NameSenaparib
Iupac Chemical Name5-fluoro-1-({4-fluoro-3-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]phenyl}methyl)quinazoline-2,4(1H,3H)-dione
SynonymsSenaparib ; IMP4297 ; IMP 4297 ; IMP-4297 ;
Molecular FormulaC24H20F2N6O3
Molecular Weight478.4598
SmileO=C(N1)N(CC2=CC=C(F)C(C(N3CCN(C4=NC=CC=N4)CC3)=O)=C2)C5=C(C(F)=CC=C5)C1=O
InChiKeyVBTUJTGLLREMNW-UHFFFAOYSA-N
InChiInChI=1S/C24H20F2N6O3/c25-17-6-5-15(14-32-19-4-1-3-18(26)20(19)21(33)29-24(32)35)13-16(17)22(34)30-9-11-31(12-10-30)23-27-7-2-8-28-23/h1-8,13H,9-12,14H2,(H,29,33,35)
CAS Number1401682-78-7
Related CAS1401683-39-3 (HCl) 1401682-78-7 (free base)

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
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FormulationSolid powder
Purity≧98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

20103002 - Senaparib | CAS 1401682-78-7

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