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Selumetinib

Catalog No.: 52571
Cas No.: 606143-52-6
Purity : 98% 
52571 - Selumetinib | CAS 606143-52-6

Catalog number : 52571

CAS number : 606143-52-6

Molecular Formula : C17H15BrClFN4O3 

Molecular Weight : 457.68 

Chemical Name : Selumetinib

Smile : Cn1cnc2c1cc(c(c2F)Nc3ccc(cc3Cl)Br)C(=O)NOCCO

InChiKey : CYOHGALHFOKKQC-UHFFFAOYSA-N

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Molecular FormulaC17H15BrClFN4O3 
Molecular Weight457.68 
Purity98% 
SmileCn1cnc2c1cc(c(c2F)Nc3ccc(cc3Cl)Br)C(=O)NOCCO
InChiKeyCYOHGALHFOKKQC-UHFFFAOYSA-N
InChiInChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
MDLMFCD11977472
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Selumetinib (AZD6244; ARRY-142886) is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. 

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