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Sardomozide HCl

Catalog No: 17030306
CAS Number: 138794-73-7
Purity: 98% 

Sardomozide , also known as SAM486A or CGP48664, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). SAM486 is more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). Preclinical testing confirmed promising antiproliferative activity. The in vitro tests showed that p53 wild-type NB cells were highly sensitive to SAM486A treatment. Most notably, SAM486A treatment resulted in the rapid accumulation of proapoptotic proteins p53 and Mdm2. 

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Chemical Information

NameSardomozide HCl
Iupac Chemical Name(E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide dihydrochloride 
SynonymsCGP 48664; CGP-48664; CGP48664; SAM 486A; SAM-486A; SAM486A; Sardomozide 
Molecular FormulaC11H16Cl2N6 
Molecular Weight303.19 
SmileCl.Cl.C(N)(=N)C1=C2CCC(C2=CC=C1)=NN/C(/N)=N/[H]
InChiKeyUHEIPGJSFDAPIC-UHFFFAOYSA-N
InChiInChI=1S/C11H14N6.2ClH/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15;;/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17);2*1H
CAS Number138794-73-7
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Ordering Information

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Formulationoff-white solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17030306 - Sardomozide HCl | CAS 138794-73-7

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