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SW044248

Catalog No.: 17011714
Cas No.: 522650-83-5
Purity : 98% 
17011714 - SW044248 | CAS 522650-83-5

Catalog number : 17011714

CAS number : 522650-83-5

Molecular Formula : C22H23N5O2S 

Molecular Weight : 421.519 

Iupac Chemical Name : 2-((5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(2-methoxyphenyl)butanamide 

Smile : C(C)N1C2=C(C=3C=CC=CC13)N=NC(=N2)SC(C(=O)NC2=C(C=CC=C2)OC)CC

InChiKey : PEVRGVRHMMZNGI-UHFFFAOYSA-N

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SynonymsSW-044248; SW 044248 
Molecular FormulaC22H23N5O2S 
Molecular Weight421.519 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileC(C)N1C2=C(C=3C=CC=CC13)N=NC(=N2)SC(C(=O)NC2=C(C=CC=C2)OC)CC
InChiKeyPEVRGVRHMMZNGI-UHFFFAOYSA-N
InChiInChI=1S/C22H23N5O2S/c1-4-18(21(28)23-15-11-7-9-13-17(15)29-3)30-22-24-20-19(25-26-22)14-10-6-8-12-16(14)27(20)5-2/h6-13,18H,4-5H2,1-3H3,(H,23,28)
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SW044248 is a potent and selective Topoisomerase I inhibitor. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortalized human bronchial cell lines. The acute transcriptional response to SW044248 in sensitive HCC4017 cells correlated significantly with inhibitors of topoisomerases and SW044248 inhibited topoisomerase 1 (Top1) but not topoisomerase 2. SW044248 inhibited Top1 differently from camptothecin and camptothecin did not show the same selective toxicity as SW044248. Elimination of Top1 by siRNA partially protected cells from SW044248, although removing Top1 was itself eventually toxic. 

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