STO-609
STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KK and CaM-KK isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities.
STO-609 inhibits the activities of recombinant CaM-KK and CaM-KK isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV). In transfected HeLa cells, STO-609 suppresses the Ca2+-induced activation of CaM-KIV in a dose-dependent manner. STO-609 can permeate cells and is a competitive inhibitor of ATP.
For research use only. We do not sell to patients.
Chemical Information
| Name | STO-609 |
|---|---|
| Iupac Chemical Name | STO-609 |
| Synonyms | N/A |
| Molecular Formula | C19H10N2O3 |
| Molecular Weight | 314.29 |
| Smile | CC(=O)O.c1ccc2c(c1)nc3n2c(=O)c4cccc5c4c3ccc5C(=O)O |
| InChiKey | WNRSTFUVBWNELX-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4) |
| CAS Number | 52029-86-4 |
| MDL | MFCD06411456 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Chemical Structure
