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STO-609

Catalog No.: 17021319
Cas No.: 52029-86-4
Purity : 98% 
17021319 - STO-609 | CAS 52029-86-4

Catalog number : 17021319

CAS number : 52029-86-4

Molecular Formula : C19H10N2O3 

Molecular Weight : 314.29 

Iupac Chemical Name : STO-609 

Smile : CC(=O)O.c1ccc2c(c1)nc3n2c(=O)c4cccc5c4c3ccc5C(=O)O

InChiKey : WNRSTFUVBWNELX-UHFFFAOYSA-N

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SynonymsN/A 
Molecular FormulaC19H10N2O3 
Molecular Weight314.29 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC(=O)O.c1ccc2c(c1)nc3n2c(=O)c4cccc5c4c3ccc5C(=O)O
InChiKeyWNRSTFUVBWNELX-UHFFFAOYSA-N
InChiInChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)
MDLMFCD06411456
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STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KK and CaM-KK isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities.

STO-609 inhibits the activities of recombinant CaM-KK and CaM-KK isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV). In transfected HeLa cells, STO-609 suppresses the Ca2+-induced activation of CaM-KIV in a dose-dependent manner. STO-609 can permeate cells and is a competitive inhibitor of ATP.

 

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