STC-15
STC-15 is a first-in-class inhibitor of RNA modification and is the first ever RNA methyltransferase inhibitor to enter clinical development. STC-15 is an oral small molecule that inhibits METTL3, an RNA methyltransferase implicated in oncology and other diseases. Certain RNA methyltransferases are important regulators of RNA sensing and innate immune activation and represent novel immune-regulatory targets.
STC-15 has also been shown to inhibit tumor growth through mechanisms involving anti-cancer immune responses such as changes in interferon signaling and synergy with T cell checkpoint blockade. In addition, this compound, has demonstrated efficacy in leukemia models via mechanisms such as inhibition of leukemia stem cell function.
For research use only. We do not sell to patients.
Chemical Information
| Name | STC-15 |
|---|---|
| Iupac Chemical Name | N-((2-(((cyclobutylmethyl)amino)methyl)-1H-indol-6-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide |
| Synonyms | STC-15; STC15 ; STC 15 |
| Molecular Formula | C24H25N5O2 |
| Molecular Weight | 415.49 |
| Smile | O=C(C(N=C3N2C=CC=C3)=CC2=O)NCC4=CC1=C(C=C4)C=C(CNCC5CCC5)N1 |
| InChiKey | MFQFZLWCFZZHAI-UHFFFAOYSA-N |
| InChi | InChI=1S/C24H25N5O2/c30-23-12-21(28-22-6-1-2-9-29(22)23)24(31)26-14-17-7-8-18-11-19(27-20(18)10-17)15-25-13-16-4-3-5-16/h1-2,6-12,16,25,27H,3-5,13-15H2,(H,26,31) |
| CAS Number | 2648257-56-9 |
| Related CAS | 2648257-56-9 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Chemical Structure
