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STA-21

Catalog No.: 16122706
Cas No.: 111540-00-2
Purity : 98% 
16122706 - STA-21 | CAS 111540-00-2

Catalog number : 16122706

CAS number : 111540-00-2

Molecular Formula : C19H14O4 

Molecular Weight : 306.31 

Iupac Chemical Name : STA-21 

Smile : C[C@H]1Cc2ccc3c(c2C(=O)C1)C(=O)c4cccc(c4C3=O)O

InChiKey : ZAWXOCUFQSQDJS-VIFPVBQESA-N

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SynonymsN/A 
Molecular FormulaC19H14O4 
Molecular Weight306.31 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileC[C@H]1Cc2ccc3c(c2C(=O)C1)C(=O)c4cccc(c4C3=O)O
InChiKeyZAWXOCUFQSQDJS-VIFPVBQESA-N
InChiInChI=1S/C19H14O4/c1-9-7-10-5-6-12-17(15(10)14(21)8-9)19(23)11-3-2-4-13(20)16(11)18(12)22/h2-6,9,20H,7-8H2,1H3/t9-/m0/s1
MDLMFCD09802288
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STA-21 is a selective STAT3 inhibitor.In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. [1] In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways. 

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