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SR1001

Catalog No.: 6111522
Cas No.: 1335106-03-0
Purity : 98% 

SR1001 is a selective ROR and ROR inverse agonist; suppresses TH17 cell differentiation and inhibits autoimmunity.

SR1001 binds specifically to the ligand-binding domains of ROR and RORt, inducing a conformational change within the ligand-binding domain that encompasses the repositioning of helix 12 and leads to diminished affinity for co-activators and increased affinity for co-repressors, resulting in suppression of the receptors' transcriptional activity. SR1001 inhibited the development of murine T(H)17 cells, as demonstrated by inhibition of interleukin-17A gene expression and protein production. Furthermore, SR1001 inhibited the expression of cytokines when added to differentiated murine or human T(H)17 cells [1]. SR1001 reduced the interaction of a coactivator TRAP220 NR box 2 peptide with ROR in a dose dependent manner(IC50=117 nM) .

 

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Chemical Information

NameSR1001
Iupac Chemical NameSR1001 
SynonymsSR-1001 
Molecular FormulaC15H13F6N3O4S2 
Molecular Weight477.4 
SmileCc1c(sc(n1)NC(=O)C)S(=O)(=O)Nc2ccc(cc2)C(C(F)(F)F)(C(F)(F)F)O
InChiKeyOZBSSKGBKHOLGA-UHFFFAOYSA-N
InChiInChI=1S/C15H13F6N3O4S2/c1-7-11(29-12(22-7)23-8(2)25)30(27,28)24-10-5-3-9(4-6-10)13(26,14(16,17)18)15(19,20)21/h3-6,24,26H,1-2H3,(H,22,23,25)
CAS Number1335106-03-0
MDLMFCD23160036
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

6111522 - SR1001 | CAS 1335106-03-0

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