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SQ22536

Catalog No.: 16122726
Cas No.: 17318-31-9
Purity : 98% 
16122726 - SQ22536 | CAS 17318-31-9

Catalog number : 16122726

CAS number : 17318-31-9

Molecular Formula : C9H11N5O 

Molecular Weight : 205.22 

Iupac Chemical Name : SQ22536 

Smile : c1nc(c2c(n1)n(cn2)C3CCCO3)N

InChiKey : UKHMZCMKHPHFOT-UHFFFAOYSA-N

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Synonyms9-(tetrahydrofuran-2-yl)-9h-purin-6-amine 
Molecular FormulaC9H11N5O 
Molecular Weight205.22 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Smilec1nc(c2c(n1)n(cn2)C3CCCO3)N
InChiKeyUKHMZCMKHPHFOT-UHFFFAOYSA-N
InChiInChI=1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)
MDLMFCD00210216
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SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 M. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.SQ22536(250 mol/L) attenuates the inhibitory effect of adenosine against ADP-induced platelet aggregation from 85 to 575%, respectively (p<0.001). SQ22536 also attenuates an increase of intraplatelet levels of cAMP by adenosine from 292 to 91 pmol/108 platelets (p<0.05). It has no effect on the platelet antiaggregant activity of inosine (1 to 4 mmol/L) and ADP-induced platelet aggregation 

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