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SPL-707

Catalog No.: 193209
Cas No.: 2195361-33-0
Purity : >98%
193209 - SPL-707  | CAS 2195361-33-0

Catalog number : 193209

CAS number : 2195361-33-0

Molecular Formula : C27H28FN5O4

Molecular Weight : 505.55

Iupac Chemical Name : (S)-2-cyclopropyl-N1-((S)-5,11-dioxo-10,11-dihydro-1H,3H,5H-spiro[benzo[d]pyrazolo[1,2-a][1,2]diazepine-2,1'-cyclopropan]-10-yl)-N4-(5-fluoro-2-methylpyridin-3-yl)succinamide

Smile : FC1=CC(NC(C[C@H](C(N[C@@H]2C(N(CC3(CC3)C4)N4C(C5=C2C=CC=C5)=O)=O)=O)C6CC6)=O)=C(C)N=C1

InChiKey : WLQXBRYTQYYCMW-REWPJTCUSA-N

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SynonymsSPL-707; SPL 707; SPL707;
Molecular FormulaC27H28FN5O4
Molecular Weight505.55
AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
SmileFC1=CC(NC(C[C@H](C(N[C@@H]2C(N(CC3(CC3)C4)N4C(C5=C2C=CC=C5)=O)=O)=O)C6CC6)=O)=C(C)N=C1
InChiKeyWLQXBRYTQYYCMW-REWPJTCUSA-N
InChiInChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1
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SPL-707 is the first selective and orally active SPPL2a inhibitor. It shows adequate selectivity against the closely related enzymes γ-secretase and SPP and a good pharmacokinetic profile in mouse and rat.

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