SKI II
SKI-II is a synthetic inhibitor of sphingosine kinase (SK) activity with IC50 of 78 M for SK1 and 45 M for SK2.
SKI II inhibits cell proliferation by suppressing the Wnt/-catenin signaling pathway. SKI II also reduces the expression of c-Myc and cyclin D1, the downstream target genes of the Wnt signaling pathway. SKI II inhibits cell proliferation by suppressing the Wnt/-catenin signaling pathway. SKI II promotes the degradation of -catenin by enhancing Wnt5A. SKI II inhibits the proliferation of HepG2 cells by blocking the Wnt/-catenin signaling pathway.
SKI-II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation. In the present study, SKI-II was administered 3-weekly i.p. to LDL-R-/- mice for 16 weeks at a dose previously demonstrated to reduce tumor growth in mice. Preliminary experiments revealed that a single administration of SKI-II produces a significant reduction of plasma S1P with the maximum (40%) observed 12 h after injection.
For research use only. We do not sell to patients.
Chemical Information
| Name | SKI II |
|---|---|
| Iupac Chemical Name | SKI II |
| Synonyms | SKI-II |
| Molecular Formula | C15H11ClN2OS |
| Molecular Weight | 302.78 |
| Smile | c1cc(ccc1c2csc(n2)Nc3ccc(cc3)O)Cl |
| InChiKey | ZFGXZJKLOFCECI-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18) |
| CAS Number | 312636-16-1 |
| MDL | MFCD00733553 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Chemical Structure
